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Monooxygenase DBH-like 1 : ウィキペディア英語版 | Monooxygenase DBH-like 1
DBH-like monooxygenase protein 1, also known as monooxygenase X, is an enzyme that in humans is encoded by the ''MOXD1'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26002 )〕 DBH-like 1 maintains many of the structural features of dopamine beta-monooxygenase DBH. Since Peptidylglycine alpha-hydroxylating monooxygenase (PHM; EC 1.14.17.3) is homologous to dopamine beta-monooxygenase (DBM; EC 1.14.17.1) this concerns a structural basis for a new family of copper type II, significantly specific for ascorbate-dependent monooxygenases〔 based on the corresponding mouse homolog.〔 The pathway of catecholamine synthesis is a possible catecholamine-binding metabolic copper enzyme domain, a neuron-like property encoding MOX without a signal sequence enzyme metabolism resolving the monooxygenase X chemical pathway〔 of an unknown substrate,〔 exogenous MOX is not secreted, and it localizes throughout the endoplasmic reticulum,〔 in both endocrine or nonendocrine cells.〔 == Deficiency ==
DBH deficiency has been treated effectively with L-threo-3,4-dihydroxyphenylserine (DOPS).
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